Technische Universität Wien
Location: Vienna, Austria
Supervisor: Prof. Dr. Benedikt Schwarz
nanoplus GmbH
Location: Gerbrunn, Germany
Supervisor: Dr. Jordan Fordyce
The problem of uneven water background absorption in the “protein range” from 1700-1500 cm-1 will be tackled by DC2. Most sensitive mid-infrared photodetectors suffer from saturation effects at large laser powers, which strongly limits their usable dynamic rage. This prevents a precise measurement of small and large signals with the same waveguide and detector. In the first step of this project, the DC will develop high-speed carrier transport optimized interband cascade detectors, which provide both high sensitivity and high saturation power levels to improve the dynamic range. In a second step, an array of these detectors will be used for simultaneous absorption measurements using varying optical path lengths to gain a higher SNR in spectral regions with very strong or very low background water absorption. Mid-IR planar waveguide with multiple channels will be fabricated in cooperation with DC1 and DC9. Advanced coupling strategies will be investigated for parallel beam coupling to the photodetector array, including metamaterial couplers and on-chip hybrid integration. DC2 would perform protein sensing experiments using different solvents, protein concentrations, and temperatures to validate the on-chip device. BSA and Whey proteins would be used as standard examples.
The approach to combine individual spectra measured at different path-lengths into one single spectrum holds the promise for improved S/N across the whole covered spectral region despite of strongly varying background (solvent)absorption. Through careful comparison with the classical approach of constant pathlength measurements the anticipated advantages will be documented on the example of protein analysis in aqueous solutions. Furthermore, by combining absorbance measurements at different effective path lengths the dynamic range in terms of concentration coverage will be significantly enlarged compared to single pathlength measurements. Finally we also expect comparison of the analytical figures of merit (LOD, linearity, dynamic range) of this approach when absorbance measurements at varying pathlengths with dispersion spectroscopy measurements.
Planned Secondment:
Paul Scherrer Institut
Ph.D. Awards From:
Technische Universität Wien
Julius-Maximilians-Universität Würzburg
N.B. Secondments are indicative and may be subject to change
This project is part of Work Package 3
for Work Package 3 Overview